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Binge Drinking In Childhood And Adolescence, Germany
German adolescents are top at boozing! In the current edition of Deutsches Arzteblatt International (Dtsch Arztebl Int 2009; 106 (19): 323 - 8), Martin Stolle et al. of the German Center for Addiction Research in Childhood and Adolescence in Hamburg report that the main change has been the increase in the number of intoxicated girls. In their article, the authors present motivating short-term interventions to counteract secondary problems.
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Genetic Factors Play Lead Role For Adolescent Crime Victims
Genes trump environment as the primary reason that some adolescents are more likely than others to be victimized by crime, according to groundbreaking research led by distinguished criminologist Kevin M. Beaver of The Florida State University.
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New York Times Examines Trend Of Posting Childbirth Videos On YouTube
The New York Times on Thursday examined how thousands of women have posted videos on YouTube showing themselves giving birth. According to the Times, the women believe the videos help "demystify" childbirth by candidly presenting the process in a manner that pregnant women and their partners otherwise might not see. Along with YouTube, Web sites like Internet chat rooms and pregnancy blogs are helping to shift dynamics between pregnant women and their care providers, the Times reports. Eileen Ehudin Beard, an adviser for the American College of Nurse-Midwives, said, "The more information you have, the more s you have, the more informed you are, the better questions you ask." However, she added that the videos could have negative effects, particularly if they make women more fearful of childbirth. The childbirth videos are relatively controversial because of their graphic nature, which has challenged some of YouTube"s rules and raised issues of propriety. Victoria Grand, the head of policy for YouTube, said that nudity generally is banned from YouTube but that the site "make[s] exceptions for videos that are educational, documentary or scientific." Most childbirth videos on YouTube are age restricted to ages 18 and older. A majority of them show home births because most U.S. hospitals prohibit patients from recording births due to liability concerns, the Times reports. Although childbirth education classes have shown edited videos of births since the 1970s, the Internet and YouTube could change the way such classes are taught, according to Jeanette Schwartz, president of the International Childbirth Education Association. She noted that most videos currently used in childbirth classes are heavily edited and out of date, adding that the YouTube videos "create a wonderful opportunity to show free, real life, candid videos in a classroom setting." Eugene Declercq, a professor at the Boston University School of Public Health, said, "A hundred and fifty years ago, women viewed birth on a pretty regular basis -- they saw their sisters of neighbors give birth." He said that changed with a trend toward hospital births beginning in the late 19th century. "But now, with YouTube, we"ve come back around and women have this opportunity to view births again," Declercq said (Wollan, New York Times, 6/11).
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A Novel Communication Role For CYP17A1 In The Progression Of Castration-Resistant Prostate Cancer

UroToday.com - This publication describes our unique finding that the steroidogenic enzyme CYP17A1 is present in prostate derived exosomes, isolated from human serum. We also describe CYP17A1 expression in human prostate tissues during castration resistant progression of cancer and identify a subcellular pattern of distribution for CYP17A1 consistent with a secretory protein in human prostate tissues, similar to that of PSA. Amongst the numerous proteins shown to be present in prostasomes we have found this key steroidogenic enzyme involved in testosterone synthesis from cholesterol. CYP17A1 is currently a target of investigational agents such as Abiraterone, which is under investigation for the treatment of advanced castration resistant disease. We postulate that this phenomenon is a cellular response triggered by upregulation of processes required for the cell to undergo cholesterol mediated steroid synthesis to testosterone and DHT within prostate tumour cells and is an adaptive resistance mechanism to depletion of androgens. Despite our inability to demonstrate metabolic enzyme activity in exosome isolates, we believe that CYP17A1 presence in the serum and its elevation in cancer patients compared with healthy controls suggests that it may be a novel diagnostic biomarker. Beyond its potential as a biomarker we propose that CYP17A1 could be playing a communication role in castrate resistant cancer development. In the absence of a supply of testicular androgens, when mechanisms involved in de novo androgen synthesis have been shown to be activated1, exosomal "life-rafts" are released from the cell, loaded with "adaptive survival messages" for other cells to host and potentially assimilate in order to enhance chances of survival. This hypothesis works on the basis that elevated cholesterol levels are observed in cancer cells during castration resistant development, which in turn has been shown to regulate an increase in the extrusion of prostate derived exosomes into the cancer microenvironment2, triggers the release of these "exosomal "life rafts". References: 1. Locke J, Guns ES, Lubik A, Adomat H, Hendy S, Wood C, Gleave ME, Nelson CC: De Novo Synthesis of Androgens as a Potential Mechanism behind Androgen-Independent Prostate Cancer Progression. Cancer Res. 2008 Aug 1;68(15):6407-15 2. Llorente A, van Deurs, B and Sandvig, K: Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. European Journal of Cell Biology 86 (2007) 405-415 Manuscript: Locke J, Fazli L, Adomat H, Smyl J, Weins K, Barr S, Lubik A, Hales B, Nelson CC, Gleave M and Tomlinson Guns ES: CYP17A1 is elevated in the serum of prostate cancer patients as compared to healthy controls. Prostate Mar 2009 [EPub ahead of print] Written by Emma Tomlinson Guns, PhD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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