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Safety And Cognitive Stability Are Key Findings In Phase IIA Trial Of New Alzheimer's Disease Treatment From Humanetics Corporation
The results of a preliminary clinical trial suggest that a new Alzheimer"s drug from Humanetics Corporation is safe for daily use and that cognitive performance in patients with mild to moderate disease remained stable during the six-week course of the trial. The lack of decline in cognitive performance was an encouraging finding to be further evaluated in a Phase IIB clinical trial.
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No Adjustment Method Fully Resolves Confounding By Indication, BUSM Researchers Find
Researchers at Boston University School of Medicine (BUSM) and Boston University School of Public Health have found that no adjustment method fully resolves confounding by indication in observational studies, meaning when the validity of a study is threatened by unmeasured confounding, it is not straightforward to determine which method of adjustment, if any, is most effective in obtaining a valid and precise estimate of effect. The study appears online in the Journal of Clinical Epidemiology.
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Likelihood Of Survival May Be Improving For Extremely Preterm Infants
Infants born extremely preterm are surviving at a high rate, with about 70 percent of infants born alive between 22 and 26 weeks of gestation in Sweden surviving at least one year, with high rates of interventions being used to improve survival, according to a study in the June 3 issue of JAMA, a theme issue on child and adolescent health.
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Caucasians Are At Higher Risk Of Developing Ewing's Sarcoma Than Other Races

The largest analysis of its kind has found that Caucasians are much more likely than people in other racial/ethnic groups to develop a rare bone and soft tissue cancer called Ewing"s sarcoma. In addition, among Caucasians with this cancer, men are more likely to die than women. Published in the August 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that examining the gender and racial differences related to Ewing"s sarcoma could provide a better understanding of the disease and could lead to improved treatments for patients. Ewing"s sarcoma has historically been a difficult cancer to treat, but evolving strategies with various chemotherapy drugs, surgery, and radiation have improved survival. Limited studies have identified risk factors for the disease, although it is clear that there are racial differences in incidence. Patients of various races also differ in how they are affected by the disease and how they respond to treatment. However, no reports from population-based cancer registries have verified these observations and no studies have addressed the potential impact of race on patients" health after they are diagnosed. To get a better sense of racial differences in a large population of patients with Ewing"s sarcoma, researchers led by Dr. Sean Scully of the University of Miami analyzed patient information from the National Cancer Institute"s Surveillance, Epidemiology and End Results (SEER) Program, the largest for cancer statistics in the United States. They identified individuals diagnosed with Ewing"s sarcoma from 1973 to 2005 and analyzed various patient- and cancer-related characteristics. The investigators found that Caucasians had the highest incidence of Ewing"s sarcoma (155 cases per 100,000), followed by Asians/Pacific Islanders (82 cases per 100,000) and African Americans (17 cases per 100,000). Those rates indicate that Caucasians are nine times as likely to be diagnosed with the disease than African -Americans. In addition, the incidence of Ewing"s sarcoma has increased significantly over the past three decades in Caucasians. While the analysis identified large differences in incidence rates among races, survival rates were similar. Finally, among Caucasians - but not among other races - women had a much higher likelihood of survival than their male counterparts. The reasons for these racial and gender differences are not clear. However, "the current study constitutes a significant step towards identification of independent demographic and clinical factors associated with improved survival and clarifies some of the associated controversies in incidence patterns that could impact on the treatment of Ewing"s sarcoma," the authors wrote. Additional studies are needed to uncover the causes for racial disparities in incidence and for gender differences in survival. Notes> Article: "Ewing"s sarcoma demonstrates racial disparities in incidence and gender related difference in outcome: An analysis of 1631 cases from the SEER database (1973-2005)." Muhammad Umar Jawad, Michael C. Cheung, Elijah S. Min, Michaela M. Schneiderbauer, Leonidas G. Koniaris, and Sean P. Scully. Published Online: June 22 2009 (DOI: 10.1002/cncr.24388); Print Issue Date: August 01, 2009. The information contained in this release is protected by copyright. Free abstracts of these articles will be available via the CANCER News Room upon online publication. Claire Greenwell American Cancer Society


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