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Addex Partner Starts First-Ever Clinical Trial Of An MGluR Positive Allosteric Modulator
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) announced today that its partner Ortho-McNeil- Janssen Pharmaceuticals Inc. (OMP) has started Phase I testing of ADX71149, a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM). This product, which has potential to treat schizophrenia, anxiety, depression and other CNS disorders, is the first PAM of any mGluR subtype to enter clinical trials. Targeting mGluR2 with a PAM is a novel approach that may offer advantages over classical drug approaches. In reaching this milestone, Addex received a EUR 1 million payment from OMP and remains eligible for additional development milestones and royalties.
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BMA Scotland GP Leader Calls On Scottish Government To Listen, Support And Work With GPs To Help Improve Patient Care
As GPs across the UK gathered in London for the Annual Conference of Local Medical Committees, Dr Dean Marshall, chairman of the BMA"s Scottish General Practitioners Committee, slammed the government for trying to strip GPs of funding and called for the profession to make decisions about general practice, not civil servants.
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Quantum Immunologics, A Major Mentor Capital Investee, Starts FDA-Authorized Breast Cancer Trials
Mentor Capital, Inc. (Pink Sheets:MNTR) announces that Quantum Immunologics, Inc. (QI) has met a significant milestone marking the beginning of its FDA-authorized breast cancer trial, the completion of the first clinical treatment injection.
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Diabetes Amputees Converge On London's O2 Arena To Campaign For Better Foot Services

Diabetes UK is today bringing together 100 people, including 20 diabetes amputees, at the "Body Worlds and Mirror of Time" exhibition at London"s O2 Arena for a photo call to highlight the fact that diabetes causes 100 amputations a week in the UK. We are calling on hospitals and primary care organisations to adopt the recommendations set out in a new Diabetes UK/NHS Diabetes report, "Putting feet first". The report calls for primary care organisations to work with hospitals and community services to ensure people with diabetes have their feet examined at least once a year, to be told if their feet are "at risk", and what to do to reduce the risk of infection. The report also calls for people with diabetes admitted to hospital for any reason to have their feet examined, and protected, and if they develop any foot problems to have it assessed by a doctor, nurse or podiatrist within 24 hours. Diabetes is the leading cause of lower-limb amputation in the world and around 5,000 people with diabetes undergo leg, foot or toe amputations each year in the UK, equivalent to 100 a week. One in three people with diabetes do not realise that having the condition puts them more at risk of having an amputation. Up to 20 per cent (÷£600m) of the ÷£3bn the NHS spends on diabetes each year goes on treating foot problems in people with diabetes, and at least ÷£252m of this is spent on amputation. People with both Type 1 and Type 2 diabetes are at risk of damage to the nerves (neuropathy) and blood supply (ischaemia) to their feet. Both neuropathy and ischaemia can lead to foot ulcers and slow-healing wounds which, if they become infected, can result in amputation. However, researchers estimate that between 49 per cent and 85 per cent of all diabetic amputations can be prevented. It"s important to remember that by keeping blood glucose, blood cholesterol and blood pressure under control people with diabetes can help to prevent complications associated with the feet. "Foot injuries or ulcers in people with diabetes need to be assessed as soon as possible by an expert team," said Bridget Turner, Head of Healthcare Policy at Diabetes UK. "The longer they are left untreated, the greater the risk of deterioration and loss of the limb, which has devastating effects on a person"s mobility and mood, reducing independence and causing disfigurement." Diabetes UK


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