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Advanced Melanoma: Vaccine Shows Therapeutic Promise
A vaccine for one of the most lethal cancers, advanced melanoma, has shown improved response rates and progression-free survival for patients when combined with the immunotherapy drug, Interleukin-2, according to researchers from The University of Texas M. D. Anderson Cancer Center.
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Viruses Are Sneakier Than We Thought
Viruses are molecular marauders, plundering cells for the res they
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Blogs Comment On Obama's Notre Dame Speech, Gallup Poll On Abortion Views, Other Topics
The following summarizes selected women"s health-related blog entries.~ "Nine Key Developments in Obama"s Notre Dame Speech," Dan Gilgoff, U.S. News & World Report"s God and Country: When speaking at the University of Notre Dame"s commencement ceremony Sunday, President Obama "devoted a good-sized chunk of the address to confronting the basis for the controversy" surrounding his invitation to speak "head on," Gilgoff writes. He goes on to list nine key points in the speech, including Obama"s decisions to acknowledge the controversy surrounding his appearance at the commencement; highlight his policy proposals of increasing adoption availability and assistance to pregnant women who carry pregnancies to term, which "go way beyond pregnancy prevention;" and voice his support for "drafting a sensible conscience clause," which represents a step away from completely rescinding the Bush administration provider "conscience" rule. Gilgoff writes that Obama also "argued, despite his hopes of achieving common ground around the hottest-button issue, the two sides in the abortion debate really are at loggerheads," adding that his statement was "incongruous with a speech that argued common ground is always possible between ideological combatants." Gilgoff also discusses media coverage of the event and the fact that "Obama never stated his pro-abortion-rights position," which likely will "rile" abortion-rights advocates. In addition, Obama "peppered his speech with shows of respect for those on the other side of the issue," according to Gilgoff. Lastly, Obama addressed the moral issue surrounding abortion, which "represents a break from Democrats who, for a long time, declined to do so," but also spoke on other moral and religious issues beyond abortion -- an important move "because most religious Americans don"t see their faith mostly in terms of stopping abortion" (Gilgoff, U.S. News & World Report"s God and Country, 5/18).~ "Has the Public Become More Opposed to Abortion?" John Sides, The Monkey Cage: Recently released polls from Gallup and the Pew Research Center were based on "hopelessly mushy" questions, and the "findings obscure far more than they reveal," Sides writes. The Gallup data showed that the percentage of people who said they are "pro-life" has risen and is larger than the percentage who calls themselves "pro-choice." The Pew data showed a decline in the percentage of people who think abortion should be legal in "all" or "most" cases, with an increase in the percentage of people who think it should be illegal in all or most cases. However, "a wider array of data do not appear to show notable trends," and the "movement appears to be among Republicans," Sides writes, adding that the two research groups "purport to show shifts in opinion that are not evident in other data." The two groups "employ vague questions that do not easily map onto actual policy debates," he continues, concluding, "Once more precise data are employed, it becomes clear that opinion strongly depends on the circumstances under which the abortion would occur" (Sides, The Monkey Cage, 5/16).~ "Discussion: Obama at Notre Dame," Washington Post"s On Faith: The Washington Post"s On Faith blog posted several entries regarding President Obama"s speech at the University of Notre Dame"s commencement ceremony. Susan Brooks Thistlewaite, a senior fellow at the Center for American Progress, writes that she "appreciated" that Obama"s speech "acknowledged that women are the central decision makers" when it comes to abortion "and that women engage in moral reasoning to make the decision." However, this has "kept religious authorities from making the connection between insights from the history of ethics and the abortion question." Brian McLaren, an evangelical pastor, writes that the speech "was an example of the kind of respectful discourse we need when grappling with issues over which we disagree, while author Susan Jacoby says that the speech and reaction from the audience "will h
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Faster, More Cost-effective DNA Test For Crime Scenes, Disease Diagnosis

Scientists in Japan are reporting development of a faster, less expensive version of the fabled polymerase chain reaction (PCR), a DNA test widely used in criminal investigations, disease diagnosis, biological research and other applications. The new method could lead to expanded use of PCR in medicine, the criminal justice system and elsewhere, the researchers say. Their study is scheduled for the July 15 issue of Analytical Chemistry, a semi-monthly journal. In the new study, Naohiro Noda and colleagues note that PCR works by "amplifying" previously undetectable traces of DNA almost like photocopiers produce multiple copies of documents. With PCR, crime scene investigators can change traces of DNA into amounts that can be identified and linked to a suspect. Biologists can produce multiple copies of individual genes to study gene function, evolution, and other topics. Doctors can amplify the DNA from microbes in a patient"s blood to diagnose an infection. Current PCR methods, however, are too expensive and cumbersome for wide use. The scientists describe development and testing of a new PCR method, called the universal QProbe system, that overcomes these problems. Existing PCR processes require several "fluorescent probes" to seek out DNA. QProbe substitutes a single "fluorescent probe" that can detect virtually any target, saving time and cutting costs. The new method also is more specific, accurately detecting DNA even in the presence of unfavorable PCR products in the samples that may interfere with quantification results. Analytical Chemistry


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