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Government Of Canada Acts To Protect Newborns And Infants From Bisphenol A In Polycarbonate Plastic Baby Bottles
The Government of Canada is moving forward with proposed regulations to prohibit the advertisement, sale and importation of polycarbonate plastic baby bottles that contain bisphenol A, otherwise known as BPA, to reduce newborn and infant exposure to this substance, announced the Honourable Leona Aglukkaq, Minister of Health.
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Celgene Announces Positive Top Line Data From Randomized Controlled Phase II Study Of Apremilast In Psoriatic Arthritis
Celgene Corporation (NASDAQ: CELG) announced the preliminary results of a phase II, multi-center, randomized, double-blind, placebo-controlled, three-arm study of apremilast - a novel, orally available small molecule that exhibits anti- inflammatory activities through the suppression of multiple pro-inflammatory mediators and cytokines - in adult patients with psoriatic arthritis (CC-10004-PSA-001). The study met its primary objective of assessment of ACR20 at 12 weeks. ACR20 is defined as the percentage of patients achieving a 20% or better improvement according to the American College of Rheumatology (ACR) criteria. ACR20 is the primary assessment utilized by the U.S. Food and Drug Administration for assessment of efficacy in psoriatic arthritis, as well as rheumatoid arthritis.
News of the day
Florida State University Scientists Unveil New Seasonal Hurricane Forecasting Model
Scientists at The Florida State University"s Center for Ocean-Atmospheric Prediction Studies (COAPS) have developed a new computer model that they hope will predict with unprecedented accuracy how many hurricanes will occur in a given season.
Nutrition

Ginseng -- Nature's Anti-Inflammatory?

Laboratory experiments have demonstrated the immunological effects of ginseng. Researchers writing in BioMed Central"s open access Journal of Translational Medicine have shown that the herb, much used in traditional Chinese and other Asian medicine, does have anti-inflammatory effects. Allan Lau led a team of researchers from the University of Hong Kong who identified seven ginseng constituents, ginsenosides, which showed immune-suppressive effects. He said, "The anti-inflammatory role of ginseng may be due to the combined effects of these ginsenosides, targeting different levels of immunological activity, and so contributing to the diverse actions of ginseng in humans". The scientists treated human immune cells with different extracts of ginseng. They found that of the nine ginsenosides they identified, seven could selectively inhibit expression of the inflammatory gene CXCL-10. Lau concludes, "Further studies will be needed to examine the potential beneficial effects of ginsenosides in the management of acute and chronic inflammatory diseases in humans". Uniquely, the researchers were able to holistically test the ginseng extract"s immune effects by using sophisticated purification technologies to identify individual constituents and define their bioactivity using genomics and bioactivity assays. After that, they reconstituted them back into a whole extract with definable individual ginsenosides for re-confirmation of effects. This potentially opens up a vigorous methodology to study medicinal herbs with state-of-the-art technologies. Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells Davy CW Lee, Cindy LH Yang, Stanley CC Chik, James CB Li, Jian-hui Rong, Godfrey CF Chan and Allan SY Lau Journal of Translational Medicine (in press) http://www.translational-medicine.com/ Graeme Baldwin BioMed Central


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