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British Medical Journal Group To Publish Themed Sports Medicine Editions Supported By International Olympic Committe
The scientific and medical publisher, BMJ Group, is to publish additional themed editions of the British Journal of Sports Medicine (BJSM), supported by the International Olympic Committee (IOC), it was announced today.
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Terminally Ill Patients And Their Physicians Delay Conversations About End-of-Life Choices, Study Finds
About half of terminally ill patients do not have discussions with their physicians regarding end-of-life choices, according to a Harvard Medical School study published in the Archives of Internal Medicine, the Boston Globe reports.The study, funded by the National Cancer Institute, examined files on 1,517 patients in California, Iowa and Alabama with metastasized lung cancer. According to the Globe, a majority of patients diagnosed with metastasized lung cancer do not survive two years. Researchers asked the patients whether a physician or other health care provider had recommended hospice care or discussed end-of-life care preferences with them. According to the study, about 49% of blacks and 43% of Hispanics had discussed end-of-life care preferences with a physician or health care provider within four to seven months of their diagnosis, compared with 53% of whites and 57% of Asians. Lead study author Haiden Huskamp, an associate professor at Harvard Medical School, said, "Patients who had unrealistic expectations about how long they had to live were much less likely to talk about hospice with their doctor." Huskamp theorized that patients who said they did not discuss end-of-life options with providers might not have completely understood their prognosis or chose to believe in a better outcome. Huskamp also said physicians typically are not well-trained to handle some delicate conversations (Lazar, Boston Globe, 5/26).
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Over Half Of People With Rheumatoid Arthritis Have Periodontitis
Over half (56%) of people with rheumatoid arthritis (RA) also have periodontitis (a chronic inflammatory disease of the gum and surrounding ligaments and bones that hold the teeth in place), displaying fewer teeth than healthy matched controls, high prevalence of oral sites presenting dental plaque and advanced attachment loss (the extent of periodontal support that has been destroyed around a tooth) (chi square p
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Hepatitis B Virus Mutations May Predict Risk Of Liver Cancer

Certain mutations in the DNA of the hepatitis B virus (HBV) are associated with the development of liver cancer and may help predict which patients with HBV infections are at increased risk of the disease, according to a large meta-analysis in the Journal of the National Cancer Institute, published online July 2. HBV infection is a known cause of hepatocellular carcinoma (HCC), the most common form of liver cancer. Previous studies have looked at whether patients with specific mutations in the viral DNA may be at increased risk of developing the cancer, but most of the studies were small and they produced conflicting results. This meta-analysis, conducted by Guangwen Cao, M.D., Ph.D., of the Second Military Medical University in Shanghai and colleagues, included 43 studies with a total of 11,582 HBV-infected participants, of whom 2,801 had HCC. The researchers found that certain mutations were associated with development of HCC and more prevalent as chronic HBV infection progressed from the asymptomatic state to liver cirrhosis or HCC. "Frequent examination of patients with chronic HBV infections for the presence of these mutations may be useful for identifying which patients require preventive antiviral treatment and for the prediction of HCC," the authors write. Steve Graff Journal of the National Cancer Institute


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