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August 1-7, 2009 Is World Breastfeeding Week
This week long observation of the importance of breastfeeding is organized by the World Breastfeeding Week organization (worldbreastfeedingweek.org). The theme this year is the importance of breastfeeding during emergency situations. It is important that when natural or man-made disasters strike that all involved remember the importance of maintaining and supporting breastfeeding of infants affected by the disaster.
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Prevention Program Helps Teens Override A Gene Linked To Risky Behavior
A family-based prevention program designed to help adolescents avoid substance use and other risky behavior proved especially effective for a group of young teens with a genetic risk factor contributing toward such behavior, according to a new study by researchers at the University of Georgia. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), components of the National Institutes of Health, supported the study, which appears in the May/June issue of Child Development.
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AARP Responds To Health Reform Scare Tactics
AARP Executive Vice President John Rother issued the following statement in response to recent commentary by Betsy McCaughey in various media outlets on health care reform measures passed or currently being considered by Congress.
Mental Health

NPs-NPR-B/pGC-cGMP Signal Pathway Is Involved In Diabetic Gastroparesis

The natriuretic peptide (NP) receptor type B (NPR-B) gene was expressed in gastric smooth muscles of normal and diabetic rats and the expression was increased in diabetic rats. These results suggest that natriuretic peptide-dependent pGC-cGMP signal is up-regulated and it may contribute to diabetic gastroparesis in STZ-induced diabetic rat. Gastroparesis (delayed gastric emptying) is frequent in diabetic patients. It is a well-recognized complication of long-standing diabetes. Symptoms of diabetic gastropathy can range from mild dyspepsia to recurrent vomiting and abdominal pain and may progress to irreversible end-stage gastric failure known as gastroparesis. Gastroparesis seriously affects the quality of life. There is deterioration in glycemic control and incapacitating symptoms such as malnutrition, water and electrolyte imbalance, and aspiration may occur. However, the pathophysiology of diabetic gastropathy and gastroparesis, including impaired fundic and pyloric relaxation and impaired electrical pacemaking, is still not delineated. A research article published in volume 15, May 7, 2009 in the World Journal of Gastroenterology addresses this problem. The research team led by Professor Zheng Lin from Department of Physiology, Yanbian University College of Medicine, used physiological, radioimmunoassy and histochemistry techniques to study the role of the NPs-NPR-B/pGC(particulate guanylate cyclase)-cGMP signal pathway in the pathophysiology of diabetic gastropathy and gastroparesis in streptozotocin (STZ)-induced diabetic rats. This study has indicated that the CNP-induced relaxation and the production of cGMP of gastric smooth muscle were potentiated in STZ-induced diabetic rats. In addition to the activity of pGC, the expression of NPR-B mRNA in gastric smooth muscle was up-regulated in diabetic rats. These results suggest that the CNP-(NPR-B)-pGC-cGMP signal pathway may be involved in the pathogenesis of diabetic gastroparesis. Reference: Cai YL, Xu DY, Li XL, Qiu ZX, Jin Z, Xu WX. C-type natriuretic-peptide-potentiated relaxation response of gastric smooth muscle in streptozotocin-induced diabetic rats. World J Gastroenterol 2009; 15(17): 2125-2131 http://www.wjgnet.com/1007-9327/15/2125.asp Correspondence to: Zheng Jin, Department of Physiology, Yanbian University School of Medicine, 1829 Juzi Rd, Yanji 133000, Jilin Province, China. Lin Tian World Journal of Gastroenterology


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