Bacteria Can Induce A Harmful Immune Response
Molecules known as type I IFNs are a central component of the protective immune response following infection with a virus. In contrast, these molecules are not normally linked to the protective immune response following infection with the bacterium Staphylococcus aureus, which is becoming a major health problem due to the emergence of methicillin-resistant (MRSA) strains. However, Alice Prince and colleagues have now determined that Staphylococcus aureus induce the production of type I IFNs by mouse and human airway cells, but these molecules are not part of a protective immune response in mice, rather they markedly enhance the severity of the pneumonia caused by Staphylococcus aureus infection.
Mental Health